Research Paper Volume 13, Issue 1 pp 1236—1250

High-fat diet induced discrepant peripheral and central nervous systems insulin resistance in APPswe/PS1dE9 and wild-type C57BL/6J mice

GLUT3 and insulin metabolism related protein expression in brain of experimental animals treated with different diets (n = 6 at least for each group). (A) GLUT3 expression in cortex and hippocampus. a: control diet-treated C57 mice; b: 60% HFD-treated C57 mice; c: control diet treated APP/PS1 mice; d: 60% HFD treated APP/PS1 mice. (B) Cortical insulin metabolism related protein expression. a: comparing with C57 60% HFD group, P P P

Figure 5. GLUT3 and insulin metabolism related protein expression in brain of experimental animals treated with different diets (n = 6 at least for each group). (A) GLUT3 expression in cortex and hippocampus. a: control diet-treated C57 mice; b: 60% HFD-treated C57 mice; c: control diet treated APP/PS1 mice; d: 60% HFD treated APP/PS1 mice. (B) Cortical insulin metabolism related protein expression. a: comparing with C57 60% HFD group, P < 0.05; b: comparing with C57 CON group, P < 0.05; c: comparing with APP/PS1 CON group, P < 0.05.