Research Paper Advance Articles

Tumor-associated macrophages promote pancreatic ductal adenocarcinoma progression by inducing epithelial-to-mesenchymal transition

Tumor-associated macrophage (TAM) density correlates with survival outcomes in pancreatic ductal adenocarcinoma (PDAC) patients. (A) Representative images show hematoxylin and eosin (H&E) and CD68 stained PDAC and adjacent normal pancreatic tissues. Note: n = 3; Scale bar = 20 μm; *P B) Representative fluorescence staining images show CD68, iNOS and CD206 expression in PDAC and adjacent normal pancreatic tissues. Scale bar = 20 μm. (C) Kaplan-Meier survival curve analysis shows overall survival rates of CD68-high (n = 28) and CD68-low (n = 28) expressing PDAC patients from Ruijin Hospital (log-rank test: P

Figure 1. Tumor-associated macrophage (TAM) density correlates with survival outcomes in pancreatic ductal adenocarcinoma (PDAC) patients. (A) Representative images show hematoxylin and eosin (H&E) and CD68 stained PDAC and adjacent normal pancreatic tissues. Note: n = 3; Scale bar = 20 μm; *P < 0.05. (B) Representative fluorescence staining images show CD68, iNOS and CD206 expression in PDAC and adjacent normal pancreatic tissues. Scale bar = 20 μm. (C) Kaplan-Meier survival curve analysis shows overall survival rates of CD68-high (n = 28) and CD68-low (n = 28) expressing PDAC patients from Ruijin Hospital (log-rank test: P < 0.01).