Research Paper Advance Articles

Reduced SULT2B1b expression alleviates ox-LDL-induced inflammation by upregulating miR-148-3P via inhibiting the IKKβ/NF-κB pathway in macrophages

SULT2B1b impedes miR-148a-3p expression in macrophages. (A) The volcano plot of miRNA profiles represents the significantly up/downregulated miRNAs in RAW264.7 cells transfected with or without Ad-shSULT2B1b. (B) Upregulated miRNA expression (miR-129-5p, miR-6995-3p, miR-155-3p, miR-148a-3p and miR-192-5p) was detected by RT-qPCR. (C) After transfection with Ad-shSULT2B1b and following stimulation with ox-LDL, miR-148a-3p levels significantly increased among the miRNAs. Data are shown as the mean±SD (n=4). **p

Figure 2. SULT2B1b impedes miR-148a-3p expression in macrophages. (A) The volcano plot of miRNA profiles represents the significantly up/downregulated miRNAs in RAW264.7 cells transfected with or without Ad-shSULT2B1b. (B) Upregulated miRNA expression (miR-129-5p, miR-6995-3p, miR-155-3p, miR-148a-3p and miR-192-5p) was detected by RT-qPCR. (C) After transfection with Ad-shSULT2B1b and following stimulation with ox-LDL, miR-148a-3p levels significantly increased among the miRNAs. Data are shown as the mean±SD (n=4). **p<0.01, ***p<0.001. ns, no significant difference.