Research Paper Volume 13, Issue 3 pp 3428—3442

Reduced SULT2B1b expression alleviates ox-LDL-induced inflammation by upregulating miR-148-3P via inhibiting the IKKβ/NF-κB pathway in macrophages


Figure 6. Mechanisms mediating the role of SULT2B1b in modulating the miR-148a-3p/IKKβ/NF-κB axis in macrophage inflammation. Stimulation with ox-LDL in Raw264.7 cells can lead to IKKβ/NF-κB pathway activation, thus inducing upregulation of TNF-α and IL-6 expression. In contrast, reduced SULT2B1b expression can increase levels of miR-148a-3p, which can target the IKKβ mRNA 3'-UTR region, resulting in reduction of IKKβ expression and suppress binding of p65 and DNA in the nucleus, which alleviates cellular inflammation and proliferation.