Research Paper Volume 13, Issue 3 pp 3443—3458

Hypoxia-inducible factor 2-alpha-dependent induction of IL-6 protects the heart from ischemia/reperfusion injury


Figure 6. The roles of the PI3K/Akt and STAT3 pathways in the protective effects of HIF2α/IL-6. (A, B) Western blotting was performed to determine the protein expression of AKT, Phos-AKT, STAT3 and Phos-STAT3 in myocardium. n = 3 per group. (C) Representative image and quantitative analysis of infarct staining with different treatments. n = 8 per group. Data represent the mean ± SEM. *P<0.05, **P<0.01, ***P<0.001 versus the indicated group.