Figure 8. Effects of HIPK3 overexpression on cell proliferation, migration, and invasion. (A, B) HIPK3 mRNA and protein expressions were successfully overexpressed in 786-O and A498 cells. (C) Cell counting kit-8 assay detected the effects of HIPK3 overexpression on the proliferation of 786-O and A498 cells. (D, E) Representative images of migration and invasion assays performed using 786-O and A498 cells with transwell and wound healing assay. Data are presented as the mean ± SD from three independent experiments. *P<0.05, **P<0.01, and ***P<0.001.