Research Paper Advance Articles

Enrichment of branched chain amino acid transaminase 1 correlates with multiple biological processes and contributes to poor survival of IDH1 wild-type gliomas

The expression pattern of BCAT1 in pan-cancer and gliomas. (A, B) The mRNA expression profiles of BCAT1 in 33 tumors and paired normal tissues were shown in bodymap and dot plot. (C) The expression pattern of BCAT1 protein in multiple cancer tissues from the Human Protein Atlas. (D) The BCAT1 expression in multiple cancer tissues from TCGA RNAseq. (E) The entire immunohistochemical staining of BCAT1 and IDH1 R132H in tissue microarray. (F) Representative images of BCAT1 and IDH1 R132H staining in three cases of glioma patients. (Case1: GBM, WHO Grade IV; Case2: Anaplastic oligodendroglioma, WHO Grade III; Case3: GBM, WHO Grade IV) (Scale: 100um) (G) Quantitative analysis of BCAT1 immunohistochemical staining in different grades of gliomas. (H) Quantitative analysis of IDH1 R132H immunohistochemical staining in IDH1 wild-type and mutant diffuse gliomas.

Figure 1. The expression pattern of BCAT1 in pan-cancer and gliomas. (A, B) The mRNA expression profiles of BCAT1 in 33 tumors and paired normal tissues were shown in bodymap and dot plot. (C) The expression pattern of BCAT1 protein in multiple cancer tissues from the Human Protein Atlas. (D) The BCAT1 expression in multiple cancer tissues from TCGA RNAseq. (E) The entire immunohistochemical staining of BCAT1 and IDH1 R132H in tissue microarray. (F) Representative images of BCAT1 and IDH1 R132H staining in three cases of glioma patients. (Case1: GBM, WHO Grade IV; Case2: Anaplastic oligodendroglioma, WHO Grade III; Case3: GBM, WHO Grade IV) (Scale: 100um) (G) Quantitative analysis of BCAT1 immunohistochemical staining in different grades of gliomas. (H) Quantitative analysis of IDH1 R132H immunohistochemical staining in IDH1 wild-type and mutant diffuse gliomas.