Research Paper Volume 13, Issue 3 pp 3680—3698

Polyglutamine-expanded ataxin3 alter specific gene expressions through changing DNA methylation status in SCA3/MJD

KEGG pathway enrichment analysis of differentially methylated regions. Totally 14 pathways were enriched. (A) KEGG pathway enriched from the hypermethylated regions in SCA3/MJD mice compared to controls. (B) KEGG pathways enriched from the hypomethylated regions in SCA3/MJD mice compared to controls. The major pathways were involved in the pathway for tumorigenesis and amino acid biosynthesis.

Figure 2. KEGG pathway enrichment analysis of differentially methylated regions. Totally 14 pathways were enriched. (A) KEGG pathway enriched from the hypermethylated regions in SCA3/MJD mice compared to controls. (B) KEGG pathways enriched from the hypomethylated regions in SCA3/MJD mice compared to controls. The major pathways were involved in the pathway for tumorigenesis and amino acid biosynthesis.