Research Paper Volume 13, Issue 3 pp 3680—3698
Polyglutamine-expanded ataxin3 alter specific gene expressions through changing DNA methylation status in SCA3/MJD
Figure 3. DNA methylation status of sequence in En1, Nkx2-1, and Otx1 and the corresponding transcriptional levels of these genes. (A) Compared to control group, the average methylation levels of sequence En1_2, En1_3, and Otx1 were higher in SCA3/MJD mice (p<0.05). While the average methylation levels of sequences Nkx2-1_2 and Nkx2-1_3 were lower in SCA3/MJD mice (p<0.05). (B) the transcriptional levels of En1, Nkx2-1 and Otx1 were significantly different between SCA3/MJD and control groups (p<0.05). No significantly differences were detected in the other genes.