Research Paper Volume 13, Issue 3 pp 3798—3818

Deciphering the correlations between aging and constipation by metabolomics and network pharmacology

Summary diagram of the pathway analysis of the differential metabolites with MetPA in the aging group (AG) (A) and the constipation group (CG) (B). The size and the color of each circle were based on the pathway impact value and P-value, respectively. Metabolic pathways are as follows: 1, Synthesis and degradation of ketone bodies; 2, D-glutamine and D-glutamate metabolism; 3, Phenylalanine, tyrosine and tryptophan biosynthesis; 4, Alanine, aspartate and glutamate metabolism; 5, Starch and sucrose metabolism; 6, Phenylalanine metabolism; 7, Pyruvate metabolism; 8, Citrate cycle (TCA cycle); 9, Arginine and proline metabolism; 10, Glycolysis / Gluconeogenesis; 11, Inositol phosphate metabolism; 12, Arginine biosynthesis; 13, Butanoate metabolism; 14, Cysteine and methionine metabolism; 15, Taurine and hypotaurine metabolism.

Figure 5. Summary diagram of the pathway analysis of the differential metabolites with MetPA in the aging group (AG) (A) and the constipation group (CG) (B). The size and the color of each circle were based on the pathway impact value and P-value, respectively. Metabolic pathways are as follows: 1, Synthesis and degradation of ketone bodies; 2, D-glutamine and D-glutamate metabolism; 3, Phenylalanine, tyrosine and tryptophan biosynthesis; 4, Alanine, aspartate and glutamate metabolism; 5, Starch and sucrose metabolism; 6, Phenylalanine metabolism; 7, Pyruvate metabolism; 8, Citrate cycle (TCA cycle); 9, Arginine and proline metabolism; 10, Glycolysis / Gluconeogenesis; 11, Inositol phosphate metabolism; 12, Arginine biosynthesis; 13, Butanoate metabolism; 14, Cysteine and methionine metabolism; 15, Taurine and hypotaurine metabolism.