Research Paper Volume 13, Issue 1 pp 61—76

Human placenta-derived mesenchymal stem cells trigger repair system in TAA-injured rat model via antioxidant effect

The recovery pathway of TAA-injured rat model according to PD-MSCs transplantation. The TAA-injured rat model lead to inflammatory response of serum, oxidative stress and fibrosis progression of liver and ovary in TAA-injured rat model. However, PD-MSCs transplantation decreased oxidative stress factors and increased antioxidants factors (e.g., SOD1 and Catalase) and functional restoration factors (e.g., Albumin and Lhx8) in liver and ovary of TAA-injured rat model. Also, functional restoration factors (e.g., Albumin, Lin28a, Lhx8 and E2) improved in liver and ovary of TAA-injured rat model. Therefore, PD-MSCs restore the liver and ovary function in TAA-injured rat model via antioxidants effect. These finding suggest new therapeutic strategy and support the fundamental mechanisms of stem cell therapy.

Figure 7. The recovery pathway of TAA-injured rat model according to PD-MSCs transplantation. The TAA-injured rat model lead to inflammatory response of serum, oxidative stress and fibrosis progression of liver and ovary in TAA-injured rat model. However, PD-MSCs transplantation decreased oxidative stress factors and increased antioxidants factors (e.g., SOD1 and Catalase) and functional restoration factors (e.g., Albumin and Lhx8) in liver and ovary of TAA-injured rat model. Also, functional restoration factors (e.g., Albumin, Lin28a, Lhx8 and E2) improved in liver and ovary of TAA-injured rat model. Therefore, PD-MSCs restore the liver and ovary function in TAA-injured rat model via antioxidants effect. These finding suggest new therapeutic strategy and support the fundamental mechanisms of stem cell therapy.