Research Paper Advance Articles

Four hub genes regulate tumor infiltration by immune cells, antitumor immunity in the tumor microenvironment, and survival outcomes in lung squamous cell carcinoma patients

Validation of the four hub genes in the TCGA-LUSC dataset. (A) The expression levels of LAPTM5, CSF1R, SLCO2B1 and C1QC mRNA in the TCGA-LUSC and adjacent normal lung tissue samples. (B) The expression levels of LAPTM5, CSF1R, SLCO2B1 and C1QC proteins in the LUSC and normal lung tissue samples based on the IHC data in The Human Protein Atlas database. (C) Correlation analysis of the mRNA expression levels of the 4 hub genes, LAPTM5, CSF1R, SLCO2B1 and C1QC in the LUSC tissues and the overall survival time of the TCGA-LUSC patients. The red line indicates TCGA-LUSC samples with high expression of the 4 hub genes (above the best-separation value, n=157), and the blue line denotes the TCGA-LUSC samples with low expression of the 4 hub genes (below best-separation value, n=209).

Figure 7. Validation of the four hub genes in the TCGA-LUSC dataset. (A) The expression levels of LAPTM5, CSF1R, SLCO2B1 and C1QC mRNA in the TCGA-LUSC and adjacent normal lung tissue samples. (B) The expression levels of LAPTM5, CSF1R, SLCO2B1 and C1QC proteins in the LUSC and normal lung tissue samples based on the IHC data in The Human Protein Atlas database. (C) Correlation analysis of the mRNA expression levels of the 4 hub genes, LAPTM5, CSF1R, SLCO2B1 and C1QC in the LUSC tissues and the overall survival time of the TCGA-LUSC patients. The red line indicates TCGA-LUSC samples with high expression of the 4 hub genes (above the best-separation value, n=157), and the blue line denotes the TCGA-LUSC samples with low expression of the 4 hub genes (below best-separation value, n=209).