Research Paper Volume 13, Issue 1 pp 1383—1409

The therapeutic significance of the novel photodynamic material TPE-IQ-2O in tumors

TPE-IQ-2O PDT targets tumor cells and promotes apoptosis. (A) The fluorescence intensities of tumor cells and normal cells incubated with different concentrations of TPE-IQ-2O were measured; λex: 430 nm, λem: 560 nm, *PPPB) TPE-IQ-2O with white light (5 W, 85 mW/cm2) irradiation killed stained LLC and A549 cells but had no significant effect on the viability of BEAS-2B cells, w/o represents the abbreviation of without in this figure. (C) The protein expression of Bax, Bcl-2 and cleaved caspase-3 was evaluated.

Figure 2. TPE-IQ-2O PDT targets tumor cells and promotes apoptosis. (A) The fluorescence intensities of tumor cells and normal cells incubated with different concentrations of TPE-IQ-2O were measured; λex: 430 nm, λem: 560 nm, *P<0.05, **P<0.01, ***P<0.001 by unpaired Student’s t-test. (B) TPE-IQ-2O with white light (5 W, 85 mW/cm2) irradiation killed stained LLC and A549 cells but had no significant effect on the viability of BEAS-2B cells, w/o represents the abbreviation of without in this figure. (C) The protein expression of Bax, Bcl-2 and cleaved caspase-3 was evaluated.