Research Paper Volume 12, Issue 24 pp 24734—24777

Biological characteristics of aging in human acute myeloid leukemia cells: the possible importance of aldehyde dehydrogenase, the cytoskeleton and altered transcriptional regulation

Figure 2. The regulated proteome in the study of elderly low-risk vs younger low-risk patients. (A) Overview of proteomic data analysis from elderly low-risk and younger low-risk patient samples. Volcano plot analysis of proteins quantified in at least five patients per group. Points (in magenta) above the non-axial horizontal grey line represent proteins with significantly different abundances (P <0.05). Heatmap of the 29 differentially expressed proteins in the elderly low-risk and younger low-risk groups. The log2 of fold change (FC) of protein levels in the elderly low-risk relative to the younger low-risk group is displayed on the right of the heatmap. (B) Gene Ontology (GO; BP, biological processes, with lilac bars; CC, cellular compartments, with light grey bars; MF, molecular functions, with yellow bars) and KEGG pathways (orange bars) analyses of upregulated and downregulated proteins in the elderly low-risk group. The various enriched GO terms and KEGG pathways are displayed on the y-axis while the corresponding –log10P values are shown on the x-axis. The number of genes associated to a specific GO term or KEGG pathway is shown on the right side of the corresponding bar. Abbreviations were used in cases of long GO term (Immunoglob. for Immunoglobulin; Pos. for Positive and Neg. for Negative).