Figure 6. Kinase prediction analysis of the high-risk vs low-risk phosphoproteome. (A) Sequence motif analysis of the ± six amino acids flanking the differentially regulated phosphorylation sites for either group. (B) KSEA of differentially regulated and unregulated phosphorylation sites. The kinase z-score (x-axis) is the normalized score for each kinase (y-axis), weighted by the number of identified substrates indicated on the right side of the plot. Significant predicted kinases with FDR <0.05 are shown.