Research Paper Volume 12, Issue 24 pp 24778—24797

L-PGDS deficiency accelerated the development of naturally occurring age-related osteoarthritis

Figure 3. Deletion of L-PGDS increased synovitis in aged L-PGDS-/- mice. Coronal sections of whole knee joints from WT and L-PGDS-/- mice at ages 3, 9 and 15 months (n=8 mice/genotype/time point) were prepared and stained with hematoxylin and eosin to asses synovium changes. (A) Representative hematoxylin and eosin staining, and (B) summed synovitis scores of WT (open symbols) and L-PGDS-/- (filled symbols) mice at ages 3, 9, and 15 months. Scale bars=100 μm. The representative sections were selected based on the average score from each experimental group. Results are presented as median with interquartile range. *p<0.05 versus WT mice.