Research Paper Volume 12, Issue 24 pp 24778—24797

L-PGDS deficiency accelerated the development of naturally occurring age-related osteoarthritis

Figure 5. Micro-CT-based microangiography of the tibial subchondral bone of WT and L-PGDS-/- mice at 3 and 9 months. Subchondral bone angiogenesis in WT and L-PGDS-/- mice at 3 (n = 5 for WT, n = 6 for L-PGDS-/-) and 9 months (n = 6 per genotype) of age was evaluated by micro-CT angiography. (A) Representative 3D micro-CT-based micro-angiography of tibial subchondral bone at 3 and 15 months. Scale bars=1 mm. (B) Quantification of vessel volume (VV) and vessel number (VN) in the subchondral bone region of WT (open symbols) and L-PGDS-/- (filled symbols) mice. Data are presented as mean ± SD.