Research Paper Volume 12, Issue 24 pp 24778—24797

L-PGDS deficiency accelerated the development of naturally occurring age-related osteoarthritis

Figure 6. Pain-related behaviours during aging in WT and L-PGDS-/- mice. (A) Mechanical allodynia (50% paw withdrawal threshold (PWT)) in WT and L-PGDS-/- mice at 3, 9 and 15 months (n = 8 mice/genotype/time point) of age. Total distance travelled (B), ambulatory time (C) and number of rears (D) during 1 h testing period. Data are presented as mean ± SD. *p<0.05 versus WT mice.