Research Paper Volume 13, Issue 1 pp 1422—1439

Functional characterization of DLK1/MEG3 locus on chromosome 14q32.2 reveals the differentiation of pituitary neuroendocrine tumors

The lncRNA landscape in 172 PitNETs. (A) Heatmap of unsupervised hierarchical clustering of the top 63 most variable genes among 31 somatotroph adenomas, 17 lactotroph adenomas, 79 gonadotroph adenomas and 45 corticotroph adenomas (|log2FC|>2, adj.P.valB–D) Volcano plots showing significantly differentially expressed genes somatotroph adenomas vs. 3 other subtypes of PitNETs (Up: red, Down: blue). (E) Volcano plots showing the AC126177.8, AC355974.2, LINC02475, MEG3, MEG9 and MiR7-3HG were the most significant lncRNAs, DEGs were identified by the R package limma, 31 somatotroph adenomas vs. 141 other subtype PitNETs.

Figure 2. The lncRNA landscape in 172 PitNETs. (A) Heatmap of unsupervised hierarchical clustering of the top 63 most variable genes among 31 somatotroph adenomas, 17 lactotroph adenomas, 79 gonadotroph adenomas and 45 corticotroph adenomas (|log2FC|>2, adj.P.val<0.001). Pathological and clinical annotations were provided. (BD) Volcano plots showing significantly differentially expressed genes somatotroph adenomas vs. 3 other subtypes of PitNETs (Up: red, Down: blue). (E) Volcano plots showing the AC126177.8, AC355974.2, LINC02475, MEG3, MEG9 and MiR7-3HG were the most significant lncRNAs, DEGs were identified by the R package limma, 31 somatotroph adenomas vs. 141 other subtype PitNETs.