Research Paper Volume 13, Issue 1 pp 1422—1439

Functional characterization of DLK1/MEG3 locus on chromosome 14q32.2 reveals the differentiation of pituitary neuroendocrine tumors

Description of DLK1/MEG3 locus in 172 PitNETs. (A) The imprinting disorders of 14q32.2 region was filtered based on genes distribution in Chromosome 14. A high-resolution profile showed the genomic positions and gene trees for DLK1/MEG3 locus. (B) The TPM values of DLK1/MEG3 and characteristic molecule in 172 PitNETs. (C) DLK1 combined transcription factors and immuophenotype could distinguish somatotroph, lactotroph, gonadotroph and corticotroph PitNET patients. *compare to control group PPP

Figure 3. Description of DLK1/MEG3 locus in 172 PitNETs. (A) The imprinting disorders of 14q32.2 region was filtered based on genes distribution in Chromosome 14. A high-resolution profile showed the genomic positions and gene trees for DLK1/MEG3 locus. (B) The TPM values of DLK1/MEG3 and characteristic molecule in 172 PitNETs. (C) DLK1 combined transcription factors and immuophenotype could distinguish somatotroph, lactotroph, gonadotroph and corticotroph PitNET patients. *compare to control group P<0.05 **P<0.01 ***P<0.001.