Research Paper Volume 13, Issue 1 pp 1440—1457

NLRC4 gene silencing-dependent blockade of NOD-like receptor pathway inhibits inflammation, reduces proliferation and increases apoptosis of dendritic cells in mice with septic shock

Highly expressed NLRC4 was found in septic shock. (A) 6 intersected genes detected among the top 70 DEGs from the microarray expression profiles of GSE95233, GSE57065, GSE8121 and GSE26378. (B) PPI network of the DEGs and septic shock-related genes (the triangle signifies the DEGs, the circle indicates the septic shock-related genes; the color of the genes shows the correlation degree with other genes, with orange coloration indicative of a high correlation degree and a blue coloration signifying a low correlation degree). (C, D) The expression of NLRC4 in septic microarray expression profiles GSE8121 and GSE26378.

Figure 1. Highly expressed NLRC4 was found in septic shock. (A) 6 intersected genes detected among the top 70 DEGs from the microarray expression profiles of GSE95233, GSE57065, GSE8121 and GSE26378. (B) PPI network of the DEGs and septic shock-related genes (the triangle signifies the DEGs, the circle indicates the septic shock-related genes; the color of the genes shows the correlation degree with other genes, with orange coloration indicative of a high correlation degree and a blue coloration signifying a low correlation degree). (C, D) The expression of NLRC4 in septic microarray expression profiles GSE8121 and GSE26378.