Research Paper Volume 13, Issue 1 pp 1440—1457

NLRC4 gene silencing-dependent blockade of NOD-like receptor pathway inhibits inflammation, reduces proliferation and increases apoptosis of dendritic cells in mice with septic shock

HE staining results illustrate the amelioration of lung tissue injury induced by septic shock in mice after DCs transfected with NLRC4-siRNA. (A) The lung tissue injury detected by HE staining (scale bar = 50 μm). (B) The lung tissue injury scores. n = 10. * p p

Figure 2. HE staining results illustrate the amelioration of lung tissue injury induced by septic shock in mice after DCs transfected with NLRC4-siRNA. (A) The lung tissue injury detected by HE staining (scale bar = 50 μm). (B) The lung tissue injury scores. n = 10. * p < 0.05 vs. the sham group. † p < 0.05 vs. the CLP and NC-siRNA groups. Data comparison among multiple groups was analyzed by one-way analysis of variance (ANOVA), followed by Tukey’s post hoc test. The experiment was repeated 3 times independently.