Figure 4. NLRC4 downregulation alleviates inflammatory reaction and reduces inflammatory cell infiltration. (A) the levels of IL-1β, TNF-α and IL-6 in lung tissues of mice with septic shock detected by ELISA. (B) inflammatory cell infiltration evidenced by F4/80 and CD45 positive levels using TUNEL staining (scale bar = 25 μm). n = 10. * p < 0.05 vs. the sham group. † p < 0.05 vs. the CLP and NC-siRNA groups. Data comparison among multiple groups was analyzed by one-way ANOVA, followed by Tukey’s post hoc test. The experiment was repeated 3 times independently.