Research Paper Volume 13, Issue 3 pp 4157—4181

CCDC167 as a potential therapeutic target and regulator of cell cycle-related networks in breast cancer

MetaCore pathway analysis of coiled-coil domain-containing protein 167 (CCDC167)-co-expressed genes in breast cancer patient databases. CCDC167-co-expressed genes in breast cancer from TCGA and METABRIC databases were acquired and identified by the Venn diagram analysis in Figure 2. These 945 genes were further exported to the MetaCore pathway analysis tool to identify gene networks and signaling pathways. The “cell cycle role of anaphase-promoting complex (APC) in cell cycle regulation” was the most significantly associated pathway. APC forms a complex with cell division cycle 20 (CDC20) or cadherin-1 (CDH1) to regulate the cell cycle.

Figure 3. MetaCore pathway analysis of coiled-coil domain-containing protein 167 (CCDC167)-co-expressed genes in breast cancer patient databases. CCDC167-co-expressed genes in breast cancer from TCGA and METABRIC databases were acquired and identified by the Venn diagram analysis in Figure 2. These 945 genes were further exported to the MetaCore pathway analysis tool to identify gene networks and signaling pathways. The “cell cycle role of anaphase-promoting complex (APC) in cell cycle regulation” was the most significantly associated pathway. APC forms a complex with cell division cycle 20 (CDC20) or cadherin-1 (CDH1) to regulate the cell cycle.