Research Paper Volume 13, Issue 3 pp 4242—4257

Oxaliplatin induces the PARP1-mediated parthanatos in oral squamous cell carcinoma by increasing production of ROS

Oxaliplatin caused mitochondrial damage in OSCC cells. (A, C) Representative images of JC-1 staining in CAL27 and SCC25 cells treated with oxaliplatin. (B, D) The fluorescence ratio of monomeric JC-1/ aggregate JC-1 in CAL27 and SCC25 cells treated with oxaliplatin. * p

Figure 3. Oxaliplatin caused mitochondrial damage in OSCC cells. (A, C) Representative images of JC-1 staining in CAL27 and SCC25 cells treated with oxaliplatin. (B, D) The fluorescence ratio of monomeric JC-1/ aggregate JC-1 in CAL27 and SCC25 cells treated with oxaliplatin. * p<0.05, **p<0.01.