Research Paper Volume 13, Issue 3 pp 4242—4257

Oxaliplatin induces the PARP1-mediated parthanatos in oral squamous cell carcinoma by increasing production of ROS

Oxaliplatin caused ROS overproduction and oxidative stress in OSCC cells. (A) Representative images of ROS fluorescence in CAL27 and SCC25 cells treated with H2O2, oxaliplatin, or oxaliplatin plus antioxidant NAC. (B) The SOD activity in CAL27 and SCC25 cells treated with or without oxaliplatin. (C) The GSH concentration in CAL27 and SCC25 cells treated with or without oxaliplatin. * p

Figure 7. Oxaliplatin caused ROS overproduction and oxidative stress in OSCC cells. (A) Representative images of ROS fluorescence in CAL27 and SCC25 cells treated with H2O2, oxaliplatin, or oxaliplatin plus antioxidant NAC. (B) The SOD activity in CAL27 and SCC25 cells treated with or without oxaliplatin. (C) The GSH concentration in CAL27 and SCC25 cells treated with or without oxaliplatin. * p<0.05.