Research Paper Volume 13, Issue 3 pp 4242—4257

Figure 9. Schematic illustration of how oxaliplatin induces the PARP1-mediated parthanatos in OSCC cells by increasing the production of ROS. Oxaliplatin induces the overproduction of ROS and then activates PARP1, which further induces mitochondrial depolarization and AIF release and promotes the nuclear translocation of AIF and MIF, finally inducing cell death (parthanatos).