Research Paper Volume 13, Issue 3 pp 4258—4273

Cross-platform genomic identification and clinical validation of breast cancer diagnostic biomarkers

Inhibition of hsa-miR-423-5p impairs proliferation and invasion of breast cancer cells. (A) In board breast cancer cell lines, hsa-miR-423-5p expression was performed for the selection of cell model prior to in vitro studies. (B, D) Both MDA-MB-231 and T47D cells were treated with siRNA inhibitor or siNC for 96h, and cell proliferation was measured by CCK-8 assays. (C, E) For migration analysis, Transwell cell assay was performed in both MDA-MB-231 and T47D cells, and invasive cells were stained with crystal violet and counted under a microscope. *P

Figure 2. Inhibition of hsa-miR-423-5p impairs proliferation and invasion of breast cancer cells. (A) In board breast cancer cell lines, hsa-miR-423-5p expression was performed for the selection of cell model prior to in vitro studies. (B, D) Both MDA-MB-231 and T47D cells were treated with siRNA inhibitor or siNC for 96h, and cell proliferation was measured by CCK-8 assays. (C, E) For migration analysis, Transwell cell assay was performed in both MDA-MB-231 and T47D cells, and invasive cells were stained with crystal violet and counted under a microscope. *P < 0.05.