Figure 1. The initiation of retinal neo-vascularization is associated with downregulation of miR-106b expression. (A) Schematic of laser burn CNV mouse model. (B) Representative retinal fundus of a mouse before and after undergoing laser-induced choroidal neovascularization. Serial images depict the progression of neovascularization over a time-course of 14 days in the same eye. Choroidal expression of miR-106b by qPCR relative to intact controls assessed (C) 3 days after burns (n=8), (D) 7 days after burns (n=13) and (E) 14 days after burns (n=10); Scale bar = 50μm. Data are expressed as the mean ± S.E.M. Unpaired Two-tailed Student’s t-test was used for the analysis, *P <0.05; **P<0.001.