Research Paper Volume 12, Issue 24 pp 24836—24852

miR-106b suppresses pathological retinal angiogenesis

Figure 4. miR-106b decreases choroidal neovascularization in a CNV mouse model. (A) Schematic of intraocular injection of LV.miR-106b or LV.shVEGFA in laser burn mouse model. (B) Burn in red (lectin), CNV in green (FITC) and merge with LV.miR-106b or LV.shVEGFA compared with LV.shGFP. (C) CNV/Burns ratios quantification after LV.miR-106b treatment (n=16 burns/4 mice) and (D) CNV/Burns ratios quantification after LV.shVEGFA treatment (n=12 burns/3 mice). Scale bar = 50μm. Data are expressed as mean ± S.E.M. Unpaired Two-tailed Student’s t-test were used *P <0.05; **P<0.001.