Research Paper Volume 12, Issue 24 pp 24836—24852

miR-106b suppresses pathological retinal angiogenesis

Figure 5. miR-106b decreases retinal neovascularization in the OIR mouse model. (A) Schematic of intraocular injection of LV.miR-106b or LV.shVEGFA in the OIR mouse model. P17 retinas were flatmounted after exposure to 75% O2, having received intraocular injection of LV.shGFP (B), LV.miR-106b (C), or LV.shVEGFA (D) and magnified (EG). Neovascular area quantification (H) after LV.miR-106b injection (n=8), and (I) LV.shVEGFA injection (n=8). Scale bars, 500 μm (BD) and 200 μm (EG). Data are expressed as mean ± S.E.M. Unpaired Two-tailed Student’s t-tests were used. *P <0.05.