Research Paper Volume 13, Issue 3 pp 4503—4521

Identification of therapeutic targets and prognostic biomarkers from the hnRNP family in invasive breast carcinoma

HNRNPU improved metastatic ability of cells by activating EMT phenotypes in BRCA cells. (A, B) Effects of HNRNPU knockdown on the proliferation of ZR-75-1 and MDA-MB-330 cells. (C–E) Representative images from the Transwell migration assays for ZR-75-1 and MDA-MB-330 cells transfected with sh-HNRNPU and sh-NT. (F–H) Representative images from the wound-healing assays for ZR-75-1 and MDA-MB-330 cells transfected with sh-HNRNPU and sh-NT. (I–L) Effects of HNRNPU knockdown on the expression of EMT signal protein detection in ZR-75-1 (I, J) and MDA-MB-330 (K, L) cells using western blotting. *P P P

Figure 8. HNRNPU improved metastatic ability of cells by activating EMT phenotypes in BRCA cells. (A, B) Effects of HNRNPU knockdown on the proliferation of ZR-75-1 and MDA-MB-330 cells. (CE) Representative images from the Transwell migration assays for ZR-75-1 and MDA-MB-330 cells transfected with sh-HNRNPU and sh-NT. (FH) Representative images from the wound-healing assays for ZR-75-1 and MDA-MB-330 cells transfected with sh-HNRNPU and sh-NT. (IL) Effects of HNRNPU knockdown on the expression of EMT signal protein detection in ZR-75-1 (I, J) and MDA-MB-330 (K, L) cells using western blotting. *P < 0.05; **P < 0.01; ***P < 0.001 compared with sh-NT.