Research Paper Volume 13, Issue 4 pp 5020—5033

Toxic effect of titanium dioxide nanoparticles on corneas in vitro and in vivo

TiO2 NPs caused apoptosis and cell cycle arrest of corneal endothelial cells. Apoptosis analysis (A) and cell cycle analysis (B) of TiO2 NPs-treated primary corneal endothelial cells by using flow cytometry. *P**P***P

Figure 3. TiO2 NPs caused apoptosis and cell cycle arrest of corneal endothelial cells. Apoptosis analysis (A) and cell cycle analysis (B) of TiO2 NPs-treated primary corneal endothelial cells by using flow cytometry. *P<0.05, **P<0.01, ***P<0.001.