Research Paper Volume 13, Issue 3 pp 4522—4551

Hsa_circ_0000199 facilitates chemo-tolerance of triple-negative breast cancer by interfering with miR-206/613-led PI3K/Akt/mTOR signaling

PI3K/AKT/mTOR signaling was modified by hsa

Figure 4. PI3K/AKT/mTOR signaling was modified by hsa_circ_0000199-miR-613/miR-206 axis in triple-negative breast cancer (TNBC). (A) Protein levels of PI3K, p-PI3K, AKT, p-AKT, mTOR and p-mTOR, as well as ratios of PI3K/p-PI3K, AKT/p-AKT and mTOR/p-mTOR, were compared among NC, si-NC, si-hsa_circ_0000199+miR-613 inhibitor and si-hsa_circ_0000199 groups. ***: P<0.001. (B) Protein levels of PI3K, p-PI3K, AKT, p-AKT, mTOR and p-mTOR, as well as ratios of PI3K/p-PI3K, AKT/p-AKT and mTOR/p-mTOR in MDA-MB-231 and MDA-MB-468 cell lines, were determined after treatments of NC, si-NC, si-hsa_circ_0000199+miR-206 inhibitor and si-hsa_circ_0000199. **: P<0.01; ***: P<0.001.