Research Paper Volume 13, Issue 3 pp 4564—4589

Overexpression of TICRR and PPIF confer poor prognosis in endometrial cancer identified by gene co-expression network analysis

Methylation status and survival analysis of the hub genes. (A) Gene methylation status of ten hub genes were validated in TCGA database. *p B) Univariate survival analysis of the hub genes using the Kaplan-Meier curve. (C) Receiver operating characteristic (ROC) curve analysis and area under the curve (AUC) statistics was applied to evaluate the capacity of real hub genes to predict overall survival of patients.

Figure 5. Methylation status and survival analysis of the hub genes. (A) Gene methylation status of ten hub genes were validated in TCGA database. *p < 0.05 compared with normal endometrial tissues. (B) Univariate survival analysis of the hub genes using the Kaplan-Meier curve. (C) Receiver operating characteristic (ROC) curve analysis and area under the curve (AUC) statistics was applied to evaluate the capacity of real hub genes to predict overall survival of patients.