Research Paper Volume 13, Issue 3 pp 4590—4604

Decreased miR-132 plays a crucial role in diabetic encephalopathy by regulating the GSK-3β/Tau pathway

miR-132 downregulates the expression of GSK-3β and GSK-3β in injured HT-22 cells in vitro. (A) The relative cell viability is nearly 60% under 200 μM H2O2, which contributes to the cellular stress state. (B) The expression levels of GSK-3β among 5 groups of different concentrations H2O2. (C) miR-132 potentially reverses the upregulated levels of GSK-3β under H2O2 treatment. (D) miR-132 potentially reverses the upregulated levels of GSK-3β under the AGEs treatment. *, **, and *** means P

Figure 5. miR-132 downregulates the expression of GSK-3β and GSK-3β in injured HT-22 cells in vitro. (A) The relative cell viability is nearly 60% under 200 μM H2O2, which contributes to the cellular stress state. (B) The expression levels of GSK-3β among 5 groups of different concentrations H2O2. (C) miR-132 potentially reverses the upregulated levels of GSK-3β under H2O2 treatment. (D) miR-132 potentially reverses the upregulated levels of GSK-3β under the AGEs treatment. *, **, and *** means P < 0.05, < 0.01, < 0.001 vs Con, n = 3 for each group.