Research Paper Volume 13, Issue 4 pp 5164—5184

Inhibition of Notch1-mediated inflammation by intermedin protects against abdominal aortic aneurysm via PI3K/Akt signaling pathway

Notch signaling and M1 polarization were activated in human aorta of AAA. Control, Patients with non-abdominal aortic aneurysm; AAA, Patients with abdominal aortic aneurysm; Negative-con, Negative control group of patients with non-abdominal aortic aneurysm; Negative-AAA, Negative control group of patients with abdominal aortic aneurysm. Immunohistochemistry of (A, B) the protein expression of NICD and hes1 in patient aortas and (C) the protein expression of M1-type macrophage marker iNOS in patient aortas.

Figure 2. Notch signaling and M1 polarization were activated in human aorta of AAA. Control, Patients with non-abdominal aortic aneurysm; AAA, Patients with abdominal aortic aneurysm; Negative-con, Negative control group of patients with non-abdominal aortic aneurysm; Negative-AAA, Negative control group of patients with abdominal aortic aneurysm. Immunohistochemistry of (A, B) the protein expression of NICD and hes1 in patient aortas and (C) the protein expression of M1-type macrophage marker iNOS in patient aortas.