Research Paper Volume 13, Issue 4 pp 5442—5460

Clinical and genomic characteristics of metabolic syndrome in colorectal cancer

Functional annotation of black module and drug response. (A). PPI network of black module genes. The known metabolic -related genes were strikingly marked in red; (B). Functional annotation for black module; (C). Correlation between drugs metabolism and metabolic –related genes, which affect major signaling pathways—IGF, EGFR, mTOR, ERK-MAPK, p53, JNK and p38-MAPK signaling. (D). The correlation of gene MetS Score and major drugs metabolism signaling pathways.

Figure 4. Functional annotation of black module and drug response. (A). PPI network of black module genes. The known metabolic -related genes were strikingly marked in red; (B). Functional annotation for black module; (C). Correlation between drugs metabolism and metabolic –related genes, which affect major signaling pathways—IGF, EGFR, mTOR, ERK-MAPK, p53, JNK and p38-MAPK signaling. (D). The correlation of gene MetS Score and major drugs metabolism signaling pathways.