Figure 4. Functional annotation of black module and drug response. (A). PPI network of black module genes. The known metabolic -related genes were strikingly marked in red; (B). Functional annotation for black module; (C). Correlation between drugs metabolism and metabolic –related genes, which affect major signaling pathways—IGF, EGFR, mTOR, ERK-MAPK, p53, JNK and p38-MAPK signaling. (D). The correlation of gene MetS Score and major drugs metabolism signaling pathways.