Figure 3. TF-based regulatory network. (A) Heat map of differentially expressed TFs. The green to red spectrum indicates low to high TF expression. (B) Volcano plot of TFs. The green dots represent down-regulated TFs, the red dots represent up-regulated TFs and the black dots represent TFs that were not significantly and differentially expressed. (C) Regulatory network of TFs and PIRGs; the green nodes represent PIRGs with hazard ratios of <1 (p < 0.05), the red nodes represent PIRGs with hazard ratios of >1 (p < 0.05), the yellow nodes represent TFs that were correlated with PIRGs in terms of their mRNA levels (correlation coefficient > 0.4 and p < 0.01), and the red lines indicate positive regulatory relationships. Abbreviations: TF, transcription factor. PIRGs, prognostic immune-related genes.