Research Paper Volume 13, Issue 4 pp 5485—5505

Tumor microenvironment characterization in triple-negative breast cancer identifies prognostic gene signature

Differential gene and pathway Analysis of Different TME Cluster of TNBC. (A) The volcano plot showing the differentially expressed gene (DEGs) between TME Cluster 1 and Cluster 2. Blue is highly expressed in Cluster 2 and red is highly expressed in Cluster1. (B) Heatmap shows the expression of DEGs between the two clusters. (C) KEGG functional enrichment analyses of the up-regulated genes in Cluster 2. (D) KEGG functional enrichment analyses of the up-regulated genes in Cluster 1. (E) Expression of four immune checkpoint molecules genes in the two clusters.

Figure 2. Differential gene and pathway Analysis of Different TME Cluster of TNBC. (A) The volcano plot showing the differentially expressed gene (DEGs) between TME Cluster 1 and Cluster 2. Blue is highly expressed in Cluster 2 and red is highly expressed in Cluster1. (B) Heatmap shows the expression of DEGs between the two clusters. (C) KEGG functional enrichment analyses of the up-regulated genes in Cluster 2. (D) KEGG functional enrichment analyses of the up-regulated genes in Cluster 1. (E) Expression of four immune checkpoint molecules genes in the two clusters.