Research Paper Volume 13, Issue 4 pp 5485—5505

Tumor microenvironment characterization in triple-negative breast cancer identifies prognostic gene signature

TME signature is a promising marker of survival in TNBC patients. (A) the HR and P-value from the eight genes in the prognostic model. (B) The survival curves for patients with high-risk and low-risk in the training set. (C) The survival curves for patients with high-risk and low-risk in the validation set. (D) Distribution of risk scores, survival profiles, and heat maps showing characteristic expressions of the low and high risky groups in the training set. Top panels indicate risk scores of patients. Middle panels depict survival status and survival time of patients distributed by risk score. Bottom panels display heatmap of expression for eight predictive factors distributed by risk score. (E) Distribution of risk scores, survival profiles, and heat maps showing characteristic expressions of low- and high-risk groups in the validation set. (F) Comparison of the predictive accuracy of the training set (GSE58812) and the validation set (METABRIC).

Figure 3. TME signature is a promising marker of survival in TNBC patients. (A) the HR and P-value from the eight genes in the prognostic model. (B) The survival curves for patients with high-risk and low-risk in the training set. (C) The survival curves for patients with high-risk and low-risk in the validation set. (D) Distribution of risk scores, survival profiles, and heat maps showing characteristic expressions of the low and high risky groups in the training set. Top panels indicate risk scores of patients. Middle panels depict survival status and survival time of patients distributed by risk score. Bottom panels display heatmap of expression for eight predictive factors distributed by risk score. (E) Distribution of risk scores, survival profiles, and heat maps showing characteristic expressions of low- and high-risk groups in the validation set. (F) Comparison of the predictive accuracy of the training set (GSE58812) and the validation set (METABRIC).