Research Paper Volume 13, Issue 4 pp 5553—5570

Melatonin protects against defects induced by Enniatin B1 during porcine early embryo development

Effect of melatonin on DNA methylation levels of genome and pluripotent genes in EB1-exposed embryos. (A–D) DNA methylation levels of genome (CenRep), Oct4, Nanog and Sox2, respectively. CON, the control group. EB1, embryos treated with EB1. MT, embryos treated with melatonin. ME, embryos treated with both melatonin and EB1. a-bValues for a given group in columns with different superscripts differ significantly (p

Figure 8. Effect of melatonin on DNA methylation levels of genome and pluripotent genes in EB1-exposed embryos. (AD) DNA methylation levels of genome (CenRep), Oct4, Nanog and Sox2, respectively. CON, the control group. EB1, embryos treated with EB1. MT, embryos treated with melatonin. ME, embryos treated with both melatonin and EB1. a-bValues for a given group in columns with different superscripts differ significantly (p < 0.05).