Research Paper Volume 13, Issue 4 pp 5607—5620

Calreticulin: a potential diagnostic and therapeutic biomarker in gallbladder cancer

GEM inhibits tumor growth and downregulates the expression of CRT and p-Akt in GBC-SD xenografts. (A) Xenografted tumors derived by GBC-SD cells treated with PBS or GEM. (B) Growth curvesin mice are presented. (C) Tumor weights were measured at the endpoint of the animal experiments. (D, E) Expression levels of CRT and p-Akt in xenograft tumor were detected by IHC.*P

Figure 6. GEM inhibits tumor growth and downregulates the expression of CRT and p-Akt in GBC-SD xenografts. (A) Xenografted tumors derived by GBC-SD cells treated with PBS or GEM. (B) Growth curvesin mice are presented. (C) Tumor weights were measured at the endpoint of the animal experiments. (D, E) Expression levels of CRT and p-Akt in xenograft tumor were detected by IHC.*P<0.05 vs. negative control. P-, phosphorylated; CRT, calreticulin; GBC, gallbladder cancer; GEM, gemcitabine.