Figure 6. GEM inhibits tumor growth and downregulates the expression of CRT and p-Akt in GBC-SD xenografts. (A) Xenografted tumors derived by GBC-SD cells treated with PBS or GEM. (B) Growth curvesin mice are presented. (C) Tumor weights were measured at the endpoint of the animal experiments. (D, E) Expression levels of CRT and p-Akt in xenograft tumor were detected by IHC.*P<0.05 vs. negative control. P-, phosphorylated; CRT, calreticulin; GBC, gallbladder cancer; GEM, gemcitabine.