Research Paper Volume 13, Issue 4 pp 5718—5747

Comprehensive analysis of macrophage-related multigene signature in the tumor microenvironment of head and neck squamous cancer


Figure 14. The relationship between FANCE and M1 macrophage marker genes. (A) OSCC line CAL-27 transfected with FANCE siRNA showed a significant down-regulation of FANCE expression. (B) The down-regulation of FANCE is associated with a decrease in the expression of prostaglandin-endoperoxide synthase 2 (PTGS2). (C) The down-regulation of FANCE was significantly related to the low expression of interferon regulatory factor 5 (IRF5).