Research Paper Volume 13, Issue 4 pp 5718—5747

Comprehensive analysis of macrophage-related multigene signature in the tumor microenvironment of head and neck squamous cancer

PPI network for macrophage signature genes. (A) The macrophage marker gene set was imported into STRING (<a href="https://string-db.org/" target="

Figure 2. PPI network for macrophage signature genes. (A) The macrophage marker gene set was imported into STRING (https://string-db.org/) to obtain the interaction of these genes, and ClueGO app was used to map the network of enrichment results. Each node is a representative enrichment pathway, the connection line of the node indicates the number of genes shared between pathways, and the color indicates the enrichment classification of the node. (B) Summary of KEGG enrichment results. The function of the gene set is enriched in phagosome, viral protein interaction with cytokine and lysosome, etc. (C) The pie chart shows the enrichment pathway of GO, including cell components, molecular functions and biological processes. Gene function is enriched in defense response, cellular ion homeostasis, and lytic vacuole, etc.