Research Paper Volume 13, Issue 4 pp 5718—5747

Comprehensive analysis of macrophage-related multigene signature in the tumor microenvironment of head and neck squamous cancer

Prognostic analysis of the top 5 genes screened by random forest in HNSC. (A) HNSC patients were divided into high and low expression groups according to the optimal cutoff value. Overexpression of FANCE predicted an improved OS based on the TCGA database (*PB) Increased expression of UTP3 was associated with poorer OS (*P=2.7×10-3). (C) Overexpression of DNAJC13 predicted a better OS (*P=9.4×10-3). (D) Increased expression of ADAMDEC1 predicted an improved OS (*P=0.7×10-3). (E) Overexpression of DNASE1L3 predicted an improved OS (*P=0.047).

Figure 4. Prognostic analysis of the top 5 genes screened by random forest in HNSC. (A) HNSC patients were divided into high and low expression groups according to the optimal cutoff value. Overexpression of FANCE predicted an improved OS based on the TCGA database (*P<0.001). (B) Increased expression of UTP3 was associated with poorer OS (*P=2.7×10-3). (C) Overexpression of DNAJC13 predicted a better OS (*P=9.4×10-3). (D) Increased expression of ADAMDEC1 predicted an improved OS (*P=0.7×10-3). (E) Overexpression of DNASE1L3 predicted an improved OS (*P=0.047).