Research Paper Volume 13, Issue 4 pp 5824—5844

Development and validation of an individual alternative splicing prognostic signature in gastric cancer

Construction and evaluation of the AS-clinical nomogram for GC patients. (A, B) RMS curves for the 23-AS event prognostic signature and the AS-clinical signature in the training and validation datasets. P-values represent the difference between the two signatures in terms of the C-index. (C) Nomogram prediction of 1-year, 3-year, and 5-year OS. For stage, 0 means TNM stage I, 1 means TNM stage II, 2 means TNM stage III, and 3 means TNM stage IV. (D) Time-dependent ROC curves for the nomogram at different time points. (E) Calibration curves of observed and predicted probabilities for the nomogram.

Figure 7. Construction and evaluation of the AS-clinical nomogram for GC patients. (A, B) RMS curves for the 23-AS event prognostic signature and the AS-clinical signature in the training and validation datasets. P-values represent the difference between the two signatures in terms of the C-index. (C) Nomogram prediction of 1-year, 3-year, and 5-year OS. For stage, 0 means TNM stage I, 1 means TNM stage II, 2 means TNM stage III, and 3 means TNM stage IV. (D) Time-dependent ROC curves for the nomogram at different time points. (E) Calibration curves of observed and predicted probabilities for the nomogram.