Research Paper Volume 13, Issue 4 pp 5845—5857

Down-regulation of estrogen-related receptor alpha (ERRα) inhibits gastric cancer cell migration and invasion in vitro and in vivo

Knockdown of ERRα inhibits the proliferation of gastric cancer cells in vivo. MGC-803 cells (ERRα and Vector) were subcutaneously inoculated into BALB/c nude mice and tumor growth was monitored. 10 days after tumor inoculation, tumor volume was measured every three days. On the 30th day, mice were sacrificed and tumor xenografts were excised from surrounding tissue and weighted. (A) Representative xenograft tumors for indicated cells were shown. (B) ERRα knockdown significantly reduced xenograft tumor growth in male nude mice by tumor volume examination. (C) ERRα knockdown significantly suppressed xenograft tumor weights. Data represent mean ± S.D, *P

Figure 8. Knockdown of ERRα inhibits the proliferation of gastric cancer cells in vivo. MGC-803 cells (ERRα and Vector) were subcutaneously inoculated into BALB/c nude mice and tumor growth was monitored. 10 days after tumor inoculation, tumor volume was measured every three days. On the 30th day, mice were sacrificed and tumor xenografts were excised from surrounding tissue and weighted. (A) Representative xenograft tumors for indicated cells were shown. (B) ERRα knockdown significantly reduced xenograft tumor growth in male nude mice by tumor volume examination. (C) ERRα knockdown significantly suppressed xenograft tumor weights. Data represent mean ± S.D, *P < 0.05, **P < 0.05.