Figure 1. The expression landscape of circulating circRNAs in HCC patients and matched control groups. (A) Cluster analysis of the different expression of the circRNAs extracted from plasma in different groups. (B) Volcano plot shows the up-regulated and down-regulated circRNAs in different groups. Higher expression levels are indicated by “red” and no significant difference is indicated by “black”. (C) Venny map for upregulated circRNAs in CRLM group comparing with CRC and CRC group comparing with healthy control group. (D) The expression of circRNAs were confirmed by RT-PCR in groups. Data were presented as plot of the mean with SEM with log-transformed. CRLM: colorectal cancer with liver metastasis; CRC: colorectal cancer without liver metastasis. *Indicated P < 0.05, n.s. indicated no significant.