Research Paper Volume 13, Issue 4 pp 5946—5966

Figure 3. Genome-wide mRNA profiles associated with AURKB expression. (A, B) Volcano plot and heatmap showed the distribution and cluster of DEGs between AURKB^high and AURKB^low patients. (C) Top 20 pathways were identified through KEGG enrichment analysis by ClusterProfiler R-package, including cell cycle, DNA replication, homologous recombination, and p53 signaling pathway, etc. (D) Significant pathways enriched by GSEA analysis of DEGs between AURKB^high and AURKB^low patients were shown here: cell cycle, DNA replication, homologous recombination, p53 signaling pathway, spliceosome, proteasome, pyrimidine metabolism, and purine metabolism. Positive values indicate a higher correlation with AURKB^high patients, while negative values indicate association with AURKB^low patients.